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Article

The P2X(7) loss-of-function Glu496Ala polymorphism affects ex vivo cytokine release and protects against the cytotoxic effects of high ATP-levels.

BMC immunology - 4 Dec 2012

Wesselius Anke, Bours Martijn J L, Arts Ilja C W, Theunisz Esther H E, Geusens Piet, Dagnelie Pieter C

Abstract excerpt

BACKGROUND: The P2X(7) receptor plays an important role in cytokine release during the inflammatory response in vivo. Polymorphisms within the P2X(7) receptor gene that lead to loss of receptor function may contribute to impaired cytokine release by immune cells. Therefore, we investigated whethe...

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Source

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Identifiers

PMID: 23210974
DOI: 10.1186/1471-2172-13-64
PMCID: PMC3526505

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23210974-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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