Article

Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits

2018-11-06

Abstract excerpt

Through forward genetic screening for mutations affecting visual system development, we identified prominent coloboma and cell-autonomous retinal neuron differentiation, lamination and retinal axon projection defects in eisspalte ( ele ) mutant zebrafish. Additional axonal deficits were present, most notably at midline axon commissures. Genetic mapping and cloning of the ele mutation showed that the affected ge...

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Identifiers and source

Literature Corpus work: 9b8187fd-7055-5dc8-a522-dc9b51701e63
DOI: 10.1101/464123

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