Article
Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition.
Cell reports - 13 Dec 2022
Potts Kathryn S, Cameron Rosannah C, Metidji Amina, Ghazale Noura, Wallace LaShanale, Leal-Cervantes Ana I, Palumbo Reid, Barajas Juan Martin, Gupta Varun, Aluri Srinivas, Pradhan Kith, Myers Jacquelyn A, McKinstry Mia, Bai Xiaoying, Choudhary Gaurav S, Shastri Aditi, Verma Amit, Obeng Esther A, Bowman Teresa V
Abstract excerpt
Hematopoietic stem and progenitor cells (HSPCs) sustain lifelong hematopoiesis. Mutations of pre-mRNA splicing machinery, especially splicing factor 3b, subunit 1 (SF3B1), are early lesions found in malignancies arising from HSPC dysfunction. However, why splicing factor deficits contribute to HSPC defects remains incompletely understood. Using zebrafish, we show that HSPC formation in sf3b1 homozygous mutants is...
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