Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Connectivity in Healthy Subjects Is Nonlinearly Modulated by the COMT and DRD2 Polymorphisms in a Functional System-Dependent Manner

30 Oct 2013

Abstract excerpt

The dopamine system is known to modulate brain function in an inverted U-shaped manner. Recently, the functional networks of the brain were categorized into two systems, a "control system" and a "processing system." However, it remains unclear whether the inverted U-shaped model of dopaminergic modulation could be applied to both of these functional systems. The catechol-O-methyltransferase (COMT) and dopamine D2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Neuroimaging Techniques and Applications
Share to Functional Brain Connectivity Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24174684
DOI: 10.1523/jneurosci.2163-13.2013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Connectivity in Healthy Subjects Is Nonlinearly Modulated by the COMT and DRD2 Polymorphisms in a Functional System-Dependent MannerPMID 24174684Read ↗

Interactions of genetic variants reveal inverse modulation patterns of dopamine system on brain gray matter volume and resting-state functional connectivity in healthy young adults.Semantic proximity Read ↗

DRD2 genotype-based variation of default mode network activity and of its relationship with striatal DAT binding.Semantic proximity Read ↗

Genetic effects on behavior are mediated by neurotransmitters and large-scale neural networks.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest.Semantic proximity Read ↗

Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults.Semantic proximity Read ↗

Genetic Variation of a DRD2 Co-expression Network is Associated with Changes in Prefrontal Function After D2 Receptors Stimulation.Semantic proximity Read ↗

Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype.Semantic proximity Read ↗

D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans.Semantic proximity Read ↗

Epistasis effects of COMT and MTHFR on inter-individual differences in mental health: under the inverted U-shaped prefrontal dopamine model.Semantic proximity Read ↗

COMT x DRD4 epistasis impacts prefrontal cortex function underlying response control.Semantic proximity Read ↗

Genetic polymorphism in catechol-O-methyltransferase associated with the functional connectivity of frontostriatal circuits in first episode schizophrenia patients.Semantic proximity Read ↗

Interaction of COMT rs4680 and BDNF rs6265 polymorphisms on functional connectivity density of the left frontal eye field in healthy young adults.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.