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Article

A polygenic score indexing a DRD2-related co-expression network is associated with striatal dopamine function.

Scientific reports - 23 Jul 2022

D'Ambrosio Enrico, Pergola Giulio, Pardiñas Antonio F, Dahoun Tarik, Veronese Mattia, Sportelli Leonardo, Taurisano Paolo, Griffiths Kira, Jauhar Sameer, Rogdaki Maria, Bloomfield Michael A P, Froudist-Walsh Sean, Bonoldi Ilaria, Walters James T R, Blasi Giuseppe, Bertolino Alessandro, Howes Oliver D

Abstract excerpt

The D2 dopamine receptor (D2R) is the primary site of the therapeutic action of antipsychotics and is involved in essential brain functions relevant to schizophrenia, such as attention, memory, motivation, and emotion processing. Moreover, the gene coding for D2R (DRD2) has been associated with schizophrenia at a genome-wide level. Recent studies have shown that a polygenic co-expression index (PCI) predicting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35871219
DOI: 10.1038/s41598-022-16442-6
PMCID: PMC9308811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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