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Article

Epistatic interaction between COMT and DTNBP1 modulates prefrontal function in mice and in humans.

Molecular psychiatry - 1 Mar 2014

Papaleo F, Burdick M C, Callicott J H, Weinberger D R

Abstract excerpt

Cognitive functions are highly heritable and the impact of complex genetic interactions, though undoubtedly important, has received little investigation. Here we show in an animal model and in a human neuroimaging experiment a consistent non-linear interaction between two genes--catechol-O-methyl transferase (COMT) and dysbindin (dys; dystrobrevin-binding protein 1 (DTNBP1))--implicated through different...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24145376
DOI: 10.1038/mp.2013.133
PMCID: PMC4845721

Genes

COMT
DTNBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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