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Article

Systems biology and in vitro validation identifies family with sequence similarity 129 member A (FAM129A) as an asthma steroid response modulator.

The Journal of allergy and clinical immunology - 1 Nov 2018

McGeachie Michael J, Clemmer George L, Hayete Boris, Xing Heming, Runge Karl, Wu Ann Chen, Jiang Xiaofeng, Lu Quan, Church Bruce, Khalil Iya, Tantisira Kelan, Weiss Scott

Abstract excerpt

BACKGROUND: Variation in response to the most commonly used class of asthma controller medication, inhaled corticosteroids, presents a serious challenge in asthma management, particularly for steroid-resistant patients with little or no response to treatment. OBJECTIVE: We applied a systems biology approach to primary clinical and genomic data to identify and validate genes that modulate steroid response in...

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Identifiers

PMID: 29410046
DOI: 10.1016/j.jaci.2017.11.059
PMCID: PMC6111005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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