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Article

A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics.

The pharmacogenomics journal - 1 Apr 2013

Duan Q L, Du R, Lasky-Su J, Klanderman B J, Partch A B, Peters S P, Irvin C G, Hanrahan J P, Lima J J, Blake K V, Liggett S B, Litonjua A A, Tantisira K G

Abstract excerpt

A pro-asthmatic culture milieu and β2-agonist (isoproterenol) were previously shown to regulate the expression of select transcription factors (TFs) within human airway epithelial and smooth muscle cells. This study tests 1116 single-nucleotide polymorphisms (SNPs) across 98 of these TF genes for association with bronchodilator response (BDR) in asthma patients. Genotyping was conducted using the Illumina...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22212731
DOI: 10.1038/tpj.2011.56
PMCID: PMC3349771

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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