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Article

Glucocorticoid-induced Changes in Gene Expression of Airway Smooth Muscle in Patients with Asthma

15 Mar 2013

Abstract excerpt

RATIONALE: Glucocorticoids are the mainstay of asthma therapy. However, it is unclear whether the benefits of glucocorticoids in asthma are merely based on antiinflammatory properties. Glucocorticoids may also alter gene expression of airway smooth muscle (ASM). We hypothesized that the gene expression profile of the ASM layer in endobronchial biopsies of patients with asthma is altered by oral glucocorticoid...

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PMID: 23491407
DOI: 10.1164/rccm.201210-1886oc

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