Article
Asthma steroid pharmacogenetics: a study strategy to identify replicated treatment responses.
Proceedings of the American Thoracic Society - 1 Jan 2004
Weiss Scott T, Lake Stephen L, Silverman Eric S, Silverman Edwin K, Richter Brent, Drazen Jeffrey M, Tantisira Kelan G
Abstract excerpt
Asthma treatment with inhaled steroids demonstrates significant between-person variability. Genetic variation could contribute to this response to inhaled glucocorticosteroids. Difficulties in performing genetic association studies are well known. We designed a test and validation strategy to assess steroid pathway candidate genes. One hundred thirty-one single nucleotide polymorphisms in 14 candidate genes in...
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