Article
Gene-based association identifies SPATA13-AS1 as a pharmacogenomic predictor of inhaled short-acting beta-agonist response in multiple population groups.
The pharmacogenomics journal - 1 Aug 2014
Padhukasahasram B, Yang J J, Levin A M, Yang M, Burchard E G, Kumar R, Kwok P-Y, Seibold M A, Lanfear D E, Williams L K
Abstract excerpt
Inhaled short-acting beta-agonist (SABA) medication is commonly used in asthma patients to rapidly reverse airway obstruction and improve acute symptoms. We performed a genome-wide association study of SABA medication response using gene-based association tests. A linear mixed model approach was first used for single-nucleotide polymorphism associations, and the results were later combined using GATES to generate...
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