Article
Interaction between the DNAH9 gene and early smoke exposure in bronchial hyperresponsiveness.
The European respiratory journal - 1 Apr 2016
Dizier Marie-Hélène, Nadif Rachel, Margaritte-Jeannin Patricia, Barton Sheila J, Sarnowski Chloé, Gagné-Ouellet Valérie, Brossard Myriam, Lavielle Nolwenn, Just Jocelyne, Lathrop Mark, Holloway John W, Laprise Catherine, Bouzigon Emmanuelle, Demenais Florence
Abstract excerpt
A previous genome-wide linkage scan of bronchial hyperresponsiveness (BHR) in the French Epidemiological study on the Genetics and Environment of Asthma (EGEA) families, performed in the presence of a gene×early-life environmental tobacco smoke (ETS) exposure interaction, showed the strongest interaction in the 17p11 region where linkage was detected only among unexposed siblings. Our goal was to conduct...
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