Article
Raising the Stakes: Loss of Efflux Pump Regulation Decreases Meropenem Susceptibility in Burkholderia pseudomallei.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 2 Jul 2018
Sarovich Derek S, Webb Jessica R, Pitman Matthew C, Viberg Linda T, Mayo Mark, Baird Robert W, Robson Jennifer M, Currie Bart J, Price Erin P
Abstract excerpt
Background: Burkholderia pseudomallei, the causative agent of the high-mortality disease melioidosis, is a gram-negative bacterium that is naturally resistant to many antibiotics. There is no vaccine for melioidosis, and effective eradication is reliant on biphasic and prolonged antibiotic administration. The carbapenem drug meropenem is the current gold standard option for treating severe melioidosis. Intrinsic...
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