Article
Loss of Methyltransferase Function and Increased Efflux Activity Leads to Doxycycline Resistance in Burkholderia pseudomallei.
Antimicrobial agents and chemotherapy - 1 Jun 2017
Webb Jessica R, Price Erin P, Currie Bart J, Sarovich Derek S
Abstract excerpt
The soil-dwelling bacterium Burkholderia pseudomallei is the causative agent of the potentially fatal disease melioidosis. The lack of a vaccine toward B. pseudomallei means that melioidosis treatment relies on prolonged antibiotic therapy, which can last up to 6 months in duration or longer. Due to intrinsic resistance, few antibiotics are effective against B. pseudomallei The lengthy treatment regimen required...
Topics
- Anti-Bacterial Agents
- Burkholderia pseudomallei
- Doxycycline
- Methyltransferases
- Microbial Sensitivity Tests
- Mutation