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Mechanisms of Antibiotic Resistance in <i>Burkholderia Pseudomallei</i> : Implications for Treatment of Melioidosis

1 Dec 2012

Abstract excerpt

Burkholderia pseudomallei is the etiologic agent of melioidosis. This multifaceted disease is difficult to treat, resulting in high morbidity and mortality. Treatment of B. pseudomallei infections is lengthy and necessitates an intensive phase (parenteral ceftazidime, amoxicillin-clavulanic acid or meropenem) and an eradication phase (oral trimethoprim-sulfamethoxazole). The main resistance mechanisms affecting...

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PMID: 23231488
DOI: 10.2217/fmb.12.116

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