Article
Characterization of ceftazidime resistance mechanisms in clinical isolates of Burkholderia pseudomallei from Australia.
PloS one - 1 Jan 2012
Sarovich Derek S, Price Erin P, Von Schulze Alex T, Cook James M, Mayo Mark, Watson Lindsey M, Richardson Leisha, Seymour Meagan L, Tuanyok Apichai, Engelthaler David M, Pearson Talima, Peacock Sharon J, Currie Bart J, Keim Paul, Wagner David M
Abstract excerpt
Burkholderia pseudomallei is a gram-negative bacterium that causes the serious human disease, melioidosis. There is no vaccine against melioidosis and it can be fatal if not treated with a specific antibiotic regimen, which typically includes the third-generation cephalosporin, ceftazidime (CAZ). There have been several resistance mechanisms described for B. pseudomallei, of which the best described are amino...
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