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Article

Emergence of ceftazidime resistance in Burkholderia pseudomallei during therapy: Clinical, phenotypic and genotypic insights from paired isolates.

Journal of global antimicrobial resistance - 1 Jun 2025

Suchartlikitwong Pintip, Saninjuk Kritsakorn, Tirapattanun Aschana, Kongsai Jindaporn, Benjatikun Watcharin, Wongsurawat Thidathip, Chirakul Sunisa

Abstract excerpt

OBJECTIVES: This study aimed to characterize the clinical, phenotypic, and genomic attributes of Burkholderia pseudomallei isolates before and after the development of decreased susceptibility to β-lactam antibiotics during therapy. METHODS: Paired B. pseudomallei isolates collected before (SCBP001) and 23 days after intravenous ceftazidime (CAZ) therapy (SCBP007) were evaluated. Minimal inhibitory concentrations...

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PMID: 40368162
DOI: 10.1016/j.jgar.2025.05.006

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