Article
Taking the next-gen step: Comprehensive antimicrobial resistance detection from Burkholderia pseudomallei.
EBioMedicine - 1 Jan 2021
Madden Danielle E, Webb Jessica R, Steinig Eike J, Currie Bart J, Price Erin P, Sarovich Derek S
Abstract excerpt
BACKGROUND: Antimicrobial resistance (AMR) poses a major threat to human health. Whole-genome sequencing holds great potential for AMR identification; however, there remain major gaps in accurately and comprehensively detecting AMR across the spectrum of AMR-conferring determinants and pathogens. METHODS: Using 16 wild-type Burkholderia pseudomallei and 25 with acquired AMR, we first assessed the performance of...
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