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Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in <i>Burkholderia pseudomallei</i>

3 Oct 2011

Abstract excerpt

Known mechanisms of resistance to β-lactam antibiotics include β-lactamase expression, altered drug target, decreased bacterial permeability, and increased drug efflux. Here, we describe a unique mechanism of β-lactam resistance in the biothreat organism Burkholderia pseudomallei (the cause of melioidosis), associated with treatment failure during prolonged ceftazidime therapy of natural infection. Detailed...

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PMID: 21969582
DOI: 10.1073/pnas.1111020108

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