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Article

Contraction of T cell richness in lung cancer brain metastases

26 Jan 2018

Abstract excerpt

Very little is known about how the adaptive immune system responds to clonal evolution and tumor heterogeneity in non-small cell lung cancer. We profiled the T-cell receptor β complementarity determining region 3 in 20 patients with fully resected non-small cell lung cancer primary lesions and paired brain metastases. We characterized the richness, abundance and overlap of T cell clones between pairs, in addition...

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PMID: 29391594
DOI: 10.1038/s41598-018-20622-8

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