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Heterogeneity of neoantigen landscape between primary lesions and their matched metastases in lung cancer

1 Apr 2020

Abstract excerpt

BACKGROUND: Personalized cancer vaccines based on tumor-derived neoantigens have shown strong and long-lasting antitumor effect in patients with some solid tumors. However, whether neoantigens identified from primary lesions could represent their metastatic lesions, and consequently the effect of vaccine therapy remained unknown. METHODS: To investigate whether neoantigens identified from primary tumors are...

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PMID: 32420064
DOI: 10.21037/tlcr.2020.03.03

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