Article
Comprehensive T cell repertoire characterization of non-small cell lung cancer.
Nature communications - 30 Jan 2020
Reuben Alexandre, Zhang Jiexin, Chiou Shin-Heng, Gittelman Rachel M, Li Jun, Lee Won-Chul, Fujimoto Junya, Behrens Carmen, Liu Xiaoke, Wang Feng, Quek Kelly, Wang Chunlin, Kheradmand Farrah, Chen Runzhe, Chow Chi-Wan, Lin Heather, Bernatchez Chantale, Jalali Ali, Hu Xin, Wu Chang-Jiun, Eterovic Agda Karina, Parra Edwin Roger, Yusko Erik, Emerson Ryan, Benzeno Sharon, Vignali Marissa, Wu Xifeng, Ye Yuanqing, Little Latasha D, Gumbs Curtis, Mao Xizeng, Song Xingzhi, Tippen Samantha, Thornton Rebecca L, Cascone Tina, Snyder Alexandra, Wargo Jennifer A, Herbst Roy, Swisher Stephen, Kadara Humam, Moran Cesar, Kalhor Neda, Zhang Jianhua, Scheet Paul, Vaporciyan Ara A, Sepesi Boris, Gibbons Don L, Robins Harlan, Hwu Patrick, Heymach John V, Sharma Padmanee, Allison James P, Baladandayuthapani Veera, Lee Jack J, Davis Mark M, Wistuba Ignacio I, Futreal P Andrew, Zhang Jianjun
Abstract excerpt
Immunotherapy targeting T cells is increasingly utilized to treat solid tumors including non-small cell lung cancer (NSCLC). This requires a better understanding of the T cells in the lungs of patients with NSCLC. Here, we report T cell repertoire analysis in a cohort of 236 early-stage NSCLC patients. T cell repertoire attributes are associated with clinicopathologic features, mutational and immune landscape. A...
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