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Article

Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis.

Journal of the American Heart Association - 30 Jan 2018

Budatha Madhusudhan, Zhang Jiasheng, Zhuang Zhen W, Yun Sanguk, Dahlman James E, Anderson Daniel G, Schwartz Martin A

Abstract excerpt

BACKGROUND: Fibronectin in endothelial basement membranes promotes endothelial inflammatory activation and atherosclerosis but also promotes plaque stability and vascular remodeling. The fibronectin receptor α5 subunit is proinflammatory through binding to and activating phosphodiesterase 4D5, which inhibits anti-inflammatory cyclic adenosine monophosphate and protein kinase A. Replacing the α5 cytoplasmic domain...

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Identifiers

PMID: 29382667
DOI: 10.1161/JAHA.117.007501
PMCID: PMC5850249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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