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Article

ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation.

Experimental & molecular medicine - 1 Feb 2023

Cho Dong Im, Ahn Min Joo, Cho Hyang Hee, Cho Meeyoung, Jun Ju Hee, Kang Bo Gyeong, Lim Soo Yeon, Yoo Soo Ji, Kim Mi Ra, Kim Hyung-Seok, Lee Su-Jin, Dat Le Thanh, Lee Changho, Kim Yong Sook, Ahn Youngkeun

Abstract excerpt

Atherosclerosis, the leading cause of death, is a vascular disease of chronic inflammation. We recently showed that angiopoietin-like 4 (ANGPTL4) promotes cardiac repair by suppressing pathological inflammation. Given the fundamental contribution of inflammation to atherosclerosis, we assessed the role of ANGPTL4 in the development of atherosclerosis and determined whether ANGPTL4 regulates atherosclerotic plaque...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kruppel-Like Factor 4

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Identifiers

PMID: 36782020
DOI: 10.1038/s12276-023-00937-x
PMCID: PMC9981608

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