Article

Fibronectin-integrin α5 signaling promotes thoracic aortic aneurysm in a mouse model of Marfan syndrome

2022-08-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Marfan syndrome, caused by mutations in the gene for the extracellular matrix (ECM) glycoprotein fibrillin-1, leads to thoracic aortic aneurysms (TAAs). Phenotypic modulation of vascular smooth muscle cells (SMCs) and ECM remodeling are characteristics of both non-syndromic and Marfan aneurysms. The ECM protein fibronectin (FN) is elevated in the tunica media of TAAs and amp...

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Literature Corpus work: 996d44b3-ce9f-5dca-a182-ce322b4984b6
DOI: 10.1101/2022.08.16.504169

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