Article
Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice.
Nature medicine - 1 Sept 2018
Gomez Delphine, Baylis Richard A, Durgin Brittany G, Newman Alexandra A C, Alencar Gabriel F, Mahan Sidney, St Hilaire Cynthia, Müller Werner, Waisman Ari, Francis Sheila E, Pinteaux Emmanuel, Randolph Gwendalyn J, Gram Hermann, Owens Gary K
Abstract excerpt
Despite decades of research, our understanding of the processes controlling late-stage atherosclerotic plaque stability remains poor. A prevailing hypothesis is that reducing inflammation may improve advanced plaque stability, as recently tested in the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial, in which post-myocardial infarction subjects were treated with an IL-1β antibody. Here, we...
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