Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania.

PloS one - 1 Jan 2014

Mtatiro Siana Nkya, Singh Tarjinder, Rooks Helen, Mgaya Josephine, Mariki Harvest, Soka Deogratius, Mmbando Bruno, Msaki Evarist, Kolder Iris, Thein Swee Lay, Menzel Stephan, Cox Sharon E, Makani Julie, Barrett Jeffrey C

Abstract excerpt

BACKGROUND: Fetal hemoglobin (HbF) is an important modulator of sickle cell disease (SCD). HbF has previously been shown to be affected by variants at three loci on chromosomes 2, 6 and 11, but it is likely that additional loci remain to be discovered. METHODS AND FINDINGS: We conducted a genome-wide association study (GWAS) in 1,213 SCA (HbSS/HbSβ0) patients in Tanzania. Genotyping was done with Illumina Omni2.5...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anemia, Sickle Cell
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Computational Biology

Share to Fetal Hemoglobin

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Tanzania

Source

Open in PubMed Open full text

Identifiers

PMID: 25372704
DOI: 10.1371/journal.pone.0111464
PMCID: PMC4221031

Genes

MYB
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania.PMID 25372704Read ↗

Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia.Semantic proximity Read ↗

Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in sickle cell disease in Tanzania.Semantic proximity Read ↗

Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer.Semantic proximity Read ↗

Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in Sickle Cell Disease in Tanzania.Semantic proximity Read ↗

Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation.Semantic proximity Read ↗

Genotyping the BCL11A Single Nucleotide Polymorphism and Associated Levels of Fetal Hemoglobin in Mauritanian Sickle Cell Patients.Semantic proximity Read ↗

Genetic variants at HbF-modifier loci moderate anemia and leukocytosis in sickle cell disease in Tanzania.Semantic proximity Read ↗

g(HbF): a genetic model of fetal hemoglobin in sickle cell disease.Semantic proximity Read ↗

FLT1 and other candidate fetal haemoglobin modifying loci in sickle cell disease in African ancestriesSemantic proximity Read ↗

A survey of genetic fetal-haemoglobin modifiers in Nigerian patients with sickle cell anaemia.Semantic proximity Read ↗

A replication study of novel fetal hemoglobin-associated genetic variants in sickle cell disease-only cohorts.Semantic proximity Read ↗

Genetics and Genomics in Sickle Cell Disease in Africa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.