Article
High throughput human genotyping for variants associated with malarial disease outcomes using custom targeted amplicon sequencing.
Scientific reports - 26 Jul 2023
Osborne Ashley, Phelan Jody E, Vanheer Leen N, Manjurano Alphaxard, Gitaka Jesse, Drakeley Christopher J, Kaneko Akira, Kita Kiyoshi, Campino Susana, Clark Taane G
Abstract excerpt
Malaria has exhibited the strongest known selective pressure on the human genome in recent history and is the evolutionary driving force behind genetic conditions, such as sickle-cell disease, glucose-6-phosphatase deficiency, and some other erythrocyte defects. Genomic studies (e.g., The 1000 Genomes project) have provided an invaluable baseline for human genetics, but with an estimated two thousand...
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