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GWAS of epigenetic aging rates in blood reveals a critical role for TERT

22 Jan 2018

Abstract excerpt

Abstract DNA methylation age is an accurate biomarker of chronological age and predicts lifespan, but its underlying molecular mechanisms are unknown. In this genome-wide association study of 9907 individuals, we find gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleration (EEAA)....

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Share to Epigenetics and DNA Methylation
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29374233
DOI: 10.1038/s41467-017-02697-5

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