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Article

A meta-analysis of genome-wide association studies of epigenetic age acceleration.

PLoS genetics - 1 Nov 2019

Gibson Jude, Russ Tom C, Clarke Toni-Kim, Howard David M, Hillary Robert F, Evans Kathryn L, Walker Rosie M, Bermingham Mairead L, Morris Stewart W, Campbell Archie, Hayward Caroline, Murray Alison D, Porteous David J, Horvath Steve, Lu Ake T, McIntosh Andrew M, Whalley Heather C, Marioni Riccardo E

Abstract excerpt

'Epigenetic age acceleration' is a valuable biomarker of ageing, predictive of morbidity and mortality, but for which the underlying biological mechanisms are not well established. Two commonly used measures, derived from DNA methylation, are Horvath-based (Horvath-EAA) and Hannum-based (Hannum-EAA) epigenetic age acceleration. We conducted genome-wide association studies of Horvath-EAA and Hannum-EAA in 13,493...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Expression Regulation

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Share to Genome-Wide Association Study

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 31738745
DOI: 10.1371/journal.pgen.1008104
PMCID: PMC6886870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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