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Article

Human genetic variations: Beacons on the pathways to successful ageing.

Mechanisms of ageing and development - 1 Sept 2009

Cluett Christie, Melzer David

Abstract excerpt

Avoiding age-related disease until late in life is key to 'successful' ageing. Over 300 genome-wide association study papers have been published. Over 50 variants have already been identified as associated with four key age-related diseases, namely cardiovascular disease, type 2 diabetes, osteoporosis and prostate cancer. We review these findings with reference to pathways linked to ageing, including cell cycle...

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PMID: 19580824
DOI: 10.1016/j.mad.2009.06.009

Genes

IGF1
TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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