Back to search

Article

GWAS of epigenetic ageing rates in blood reveals a critical role for <i>TERT</i>

2017-06-30

Abstract excerpt

DNA methylation age is an accurate biomarker of chronological age and predicts lifespan, but its underlying molecular mechanisms are unknown. In this genome-wide association study of 9,907 individuals, we found gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in 3 loci associated extrinsic epigenetic age acceleration (EEAA). Mendelian randomization a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c1520e69-ec59-5b19-821b-14241aee810f
DOI
10.1101/157776
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
GWAS of epigenetic ageing rates in blood reveals a critical role for <i>TERT</i>DOI 10.1101/157776
GWAS of epigenetic aging rates in blood reveals a critical role for TERTSemantic proximity
Genetically Proxied Telomere Length but Not Epigenetic Aging Acceleration Causally Influences Healthspan: A Mendelian Randomization StudySemantic proximity
Human genetic variations: Beacons on the pathways to successful ageing.Semantic proximity
Human Aging DNA Methylation Signatures are Conserved but Accelerated in Cultured FibroblastsSemantic proximity
Menopause accelerates biological aging.Semantic proximity
A genome-wide association study identifies a locus on TERT for mean telomere length in Han Chinese.Semantic proximity
Frailty is associated with the epigenetic clock but not with telomere length in a German cohortSemantic proximity
Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblastsSemantic proximity
DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility.Semantic proximity
A meta-analysis of genome-wide association studies of epigenetic age acceleration.Semantic proximity
The epigenetic clock: a molecular crystal ball for human aging?Semantic proximity
Genetically Determined Telomere Length and Risk for Haematologic Diseases: Results from Large Prospective Cohorts and Mendelian Randomization AnalysisSemantic proximity
Select a neighboring publication to make it the new centre.