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Article

Genetic variation in APOE cluster region and Alzheimer's disease risk.

Neurobiology of aging - 1 Nov 2011

Cervantes Sebastián, Samaranch Lluís, Vidal-Taboada José Manuel, Lamet Isabel, Bullido María Jesús, Frank-García Ana, Coria Francisco, Lleó Albert, Clarimón Jordi, Lorenzo Elena, Alonso Elena, Sánchez-Juan Pascual, Rodríguez-Rodríguez Eloy, Combarros Onofre, Rosich Marcel, Vilella Elisabet, Pastor Pau

Abstract excerpt

We report the fine mapping/sequencing results of promoter and regulatory regions of APOE cluster genes (APOE, APOC1, APOC4, APOC2, and TOMM40) in Alzheimer's disease (AD) risk as well as in the progression from mild cognitive impairment (MCI) to AD. Long-range sequencing in 29 MCI subjects who progressed to dementia revealed 7 novel variants. Two potentially relevant novel variants and 34 single nucleotide...

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Source

Identifiers

PMID: 21752496
DOI: 10.1016/j.neurobiolaging.2011.05.023

Genes

APOE
APOC2
APOC4
TOMM40
APOC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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