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Article

Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel.

Science signaling - 23 Jan 2018

Zimova Lucie, Sinica Viktor, Kadkova Anna, Vyklicka Lenka, Zima Vlastimil, Barvik Ivan, Vlachova Viktorie

Abstract excerpt

Transient receptor potential ankyrin 1 (TRPA1) is a temperature-sensitive ion channel activated by various pungent and irritant compounds that can produce pain in humans. Its activation involves an allosteric mechanism whereby electrophilic agonists evoke interactions within cytosolic domains and open the channel pore through an integrated nexus formed by intracellular membrane proximal regions that are densely...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29363587
DOI: 10.1126/scisignal.aan8621

Genes

TRPA1

Provenance

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Related research

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Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel.PMID 29363587Read ↗

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