Article
The region adjacent to the C-end of the inner gate in transient receptor potential melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation.
The Journal of biological chemistry - 10 Oct 2014
Taberner Francisco José, López-Córdoba Ainara, Fernández-Ballester Gregorio, Korchev Yuri, Ferrer-Montiel Antonio
Abstract excerpt
The ability of transient receptor potential (TRP) channels to sense and respond to environmental and endogenous cues is crucial in animal sensory physiology. The molecular mechanism of channel gating is yet elusive. The TRP box, a conserved region in the N-end of the C terminus domain, has been signaled as pivotal for allosteric activation in TRP channels. Here, we have examined the role of the linker region...
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