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Article

Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel.

Biochimica et biophysica acta - 1 Jul 2009

Benedikt Jan, Samad Abdul, Ettrich Rudiger, Teisinger Jan, Vlachova Viktorie

Abstract excerpt

The ankyrin transient receptor potential channel TRPA1 is a sensory neuron-specific channel that is gated by various proalgesic agents such as allyl isothiocyanate (AITC), deep cooling or highly depolarizing voltages. How these disparate stimuli converge on the channel protein to open/close its ion-conducting pore is unknown. We identify several residues within the S6 inner pore-forming region of human TRPA1 that...

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Source

Identifiers

PMID: 19422860
DOI: 10.1016/j.bbamcr.2009.04.014

Genes

TRPA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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