Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure-based selection of human metabolite binding P4 pocket of DRB115:01 and DRB115:03, with implications for multiple sclerosis.

Genes and immunity - 1 Jan 2019

Misra Maneesh K, Damotte Vincent, Hollenbach Jill A

Abstract excerpt

Binding of small molecules in the human leukocyte antigen (HLA) peptide-binding groove may result in conformational changes of bound peptide and an altered immune response, but previous studies have not considered a potential role for endogenous metabolites. We performed virtual screening of the complete Human Metabolite Database (HMDB) for docking to the multiple sclerosis (MS) susceptible DRB1*15:01 allele and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Binding Sites
Share to MBP gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA-DRB1 Chains

Share to Molecular Docking Simulation

Share to Multiple Sclerosis

Share to Myelin Basic Protein

Share to Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 29362509
DOI: 10.1038/s41435-017-0009-5
PMCID: PMC6054566

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure-based selection of human metabolite binding P4 pocket of DRB1*15:01 and DRB1*15:03, with implications for multiple sclerosis.PMID 29362509Read ↗

Deconstruction of HLA-DRB1*04:01:01 and HLA-DRB1*15:01:01 class II haplotypes using next-generation sequencing in European-Americans with multiple sclerosisSemantic proximity Read ↗

Antigenic peptide molecular recognition by the DRB1-DQB1 haplotype modulates multiple sclerosis susceptibility.Semantic proximity Read ↗

Distinct conformations of a peptide bound to HLA-DR1 or DRB5*0101 suggested by molecular modelling.Semantic proximity Read ↗

An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene.Semantic proximity Read ↗

In silico study of the association of the HLA-A*31:01 allele (human leucocyte antigen allele 31:01) with neuroantigenic epitopes of PLP (proteolipid protein), MBP (myelin basic protein) and MOG proteins (myelin oligodendrocyte glycoprotein) for studying the multiple sclerosis disease pathogenesis.Semantic proximity Read ↗

Ligand motifs of HLA-DRB5*0101 and DRB1*1501 molecules delineated from self-peptides.Semantic proximity Read ↗

HLA-DRB1*15:01 is associated with a reduced likelihood of longevity in northern European men.Semantic proximity Read ↗

Electrostatic modifications of the human leukocyte antigen-DR P9 peptide-binding pocket and susceptibility to primary sclerosing cholangitis.Semantic proximity Read ↗

In-Silico Design of Peptides for Inhibition of HLA-A*03-KLIETYFSK Complex as a New Drug Design for Treatment of Multiples Sclerosis DiseaseSemantic proximity Read ↗

HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility.Semantic proximity Read ↗

Vitamin D receptor (VDR) gene SNPs influence VDR expression and modulate protection from multiple sclerosis in HLA-DRB1*15-positive individuals.Semantic proximity Read ↗

Identification of Potential Antibody Epitopes in MMP-15Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.