Article
Distinct conformations of a peptide bound to HLA-DR1 or DRB5*0101 suggested by molecular modelling.
International immunology - 1 Nov 1996
Jurcevic S, Travers P J, Hills A, Agrewala J N, Moreno C, Ivanyi J
Abstract excerpt
The conformation of peptides when bound to different HLA class II molecules is of interest in the study of specificity and function of responding T cells. Here, we report the investigation of the HLA-DR binding profiles of an immunodominant and HLA-promiscuous mycobacterial peptide, p38G. Its bin...
Topics
- Alleles
- HLA-DR Antigens
- HLA-DR1 Antigen
- HLA-DRB5 Chains
- Humans
- Models, Molecular
- Peptides
- Protein Binding
- Protein Conformation