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Article

HLA-DRB1*15:01 is associated with a reduced likelihood of longevity in northern European men.

Genome medicine - 20 Oct 2025

Mendoza-Mejía Nicolás, Kolbe Daniel, Özer Onur, Dose Janina, Torres Guillermo G, Franke Andre, Nygaard Marianne, Nebel Almut

Abstract excerpt

BACKGROUND: Prior research on the genetics of human longevity has identified only a few robust associations. While these studies highlight the importance of metabolic processes for longevity, the contribution of immune genes, specifically those in the highly polymorphic human leukocyte antigen (HLA) region, remains understudied. Here, we addressed this gap by analysing the influence of HLA variation on longevity...

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PMID: 41116190
DOI: 10.1186/s13073-025-01554-1
PMCID: PMC12539080

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