Article
An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene.
BMC medical genetics - 4 Feb 2009
Ramagopalan Sreeram V, McMahon Roisin, Dyment David A, Sadovnick A Dessa, Ebers George C, Wittkowski Knut M
Abstract excerpt
BACKGROUND: Multiple sclerosis (MS) is a complex trait in which genes in the MHC class II region exert the single strongest effect on genetic susceptibility. The principal MHC class II haplotype that increases MS risk in individuals of Northern European descent are those that bear HLA-DRB1*15. However, several other HLA-DRB1 alleles have been positively and negatively associated with MS and each of the main...
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