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Article

Electrostatic modifications of the human leukocyte antigen-DR P9 peptide-binding pocket and susceptibility to primary sclerosing cholangitis.

Hepatology (Baltimore, Md.) - 1 Jun 2011

Hov Johannes R, Kosmoliaptsis Vasilis, Traherne James A, Olsson Marita, Boberg Kirsten M, Bergquist Annika, Schrumpf Erik, Bradley J Andrew, Taylor Craig J, Lie Benedicte A, Trowsdale John, Karlsen Tom H

Abstract excerpt

UNLABELLED: The strongest genetic risk factors for primary sclerosing cholangitis (PSC) are found in the human leukocyte antigen (HLA) complex at chromosome 6p21. Genes in the HLA class II region encode molecules that present antigen to T lymphocytes. Polymorphisms in these genes are associated with most autoimmune diseases, most likely because they contribute to the specificity of immune responses. The aim of...

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Identifiers

PMID: 21413052
DOI: 10.1002/hep.24299
PMCID: PMC3128712

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