Article
Ligand motifs of HLA-DRB5*0101 and DRB1*1501 molecules delineated from self-peptides.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 1994
Vogt A B, Kropshofer H, Kalbacher H, Kalbus M, Rammensee H G, Coligan J E, Martin R
Abstract excerpt
Antigenic peptides are presented to CD4+ T cells by MHC class II molecules via a highly polymorphic peptide-binding groove. The two HLA-DR alleles isotypically expressed on HLA-DR15Dw2-positive cells, DRB1*1501 (DR2b) and DRB5*0101 (DR2a) molecules, show a number of differences in polymorphic res...
Topics
- Alleles
- Amino Acid Sequence
- Autoantigens
- HLA-DR Antigens
- HLA-DRB1 Chains
- HLA-DRB5 Chains
- Histocompatibility Antigens Class II
- Humans
- Ligands
- Molecular Sequence Data
- Myelin Basic Protein
- Peptides
- Protein Structure, Tertiary
- Sequence Alignment
- Structure-Activity Relationship