Article
The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior.
Scientific reports - 17 Oct 2016
Balsamo Michele, Mondal Chandrani, Carmona Guillaume, McClain Leslie M, Riquelme Daisy N, Tadros Jenny, Ma Duan, Vasile Eliza, Condeelis John S, Lauffenburger Douglas A, Gertler Frank B
Abstract excerpt
During tumor progression, alternative splicing gives rise to different Mena protein isoforms. We analyzed how Mena11a, an isoform enriched in epithelia and epithelial-like cells, affects Mena-dependent regulation of actin dynamics and cell behavior. While other Mena isoforms promote actin polymerization and drive membrane protrusion, we find that Mena11a decreases actin polymerization and growth factor-stimulated...
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