Article
c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells.
Molecular and cellular biology - 1 Sept 2012
Björkblom Benny, Padzik Artur, Mohammad Hasan, Westerlund Nina, Komulainen Emilia, Hollos Patrik, Parviainen Lotta, Papageorgiou Anastassios C, Iljin Kristiina, Kallioniemi Olli, Kallajoki Markku, Courtney Michael J, Mågård Mats, James Peter, Coffey Eleanor T
Abstract excerpt
Cell migration is a fundamental biological function, critical during development and regeneration, whereas deregulated migration underlies neurological birth defects and cancer metastasis. MARCKS-like protein 1 (MARCKSL1) is widely expressed in nervous tissue, where, like Jun N-terminal protein kinase (JNK), it is required for neural tube formation, though the mechanism is unknown. Here we show that MARCKSL1 is...
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