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Article

Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity.

Molecular and cellular biology - 1 Nov 2013

von Thun Anne, Preisinger Christian, Rath Oliver, Schwarz Juliane P, Ward Chris, Monsefi Naser, Rodríguez Javier, Garcia-Munoz Amaya, Birtwistle Marc, Bienvenut Willy, Anderson Kurt I, Kolch Walter, von Kriegsheim Alex

Abstract excerpt

In certain Ras mutant cell lines, the inhibition of extracellular signal-regulated kinase (ERK) signaling increases RhoA activity and inhibits cell motility, which was attributed to a decrease in Fra-1 levels. Here we report a Fra-1-independent augmentation of RhoA signaling during short-term inhibition of ERK signaling. Using mass spectrometry-based proteomics, we identified guanine exchange factor H1 (GEF-H1)...

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Identifiers

PMID: 24043311
DOI: 10.1128/MCB.00585-13
PMCID: PMC3838172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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