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Article

A nuclear export signal and phosphorylation regulate Dok1 subcellular localization and functions.

Molecular and cellular biology - 1 Jun 2006

Niu Yamei, Roy François, Saltel Frédéric, Andrieu-Soler Charlotte, Dong Wen, Chantegrel Anne-Lise, Accardi Rosita, Thépot Amélie, Foiselle Nadège, Tommasino Massimo, Jurdic Pierre, Sylla Bakary S

Abstract excerpt

Dok1 is believed to be a mainly cytoplasmic adaptor protein which down-regulates mitogen-activated protein kinase activation, inhibits cell proliferation and transformation, and promotes cell spreading and cell migration. Here we show that Dok1 shuttles between the nucleus and cytoplasm. Treatmen...

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Identifiers

PMID: 16705178
DOI: 10.1128/MCB.01817-05
PMCID: PMC1489083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16705178-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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