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Article

Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma.

Disease models & mechanisms - 29 Jan 2018

Zhang Youming, Poobalasingam Thanushiyan, Yates Laura L, Walker Simone A, Taylor Martin S, Chessum Lauren, Harrison Jackie, Tsaprouni Loukia, Adcock Ian M, Lloyd Clare M, Cookson William O, Moffatt Miriam F, Dean Charlotte H

Abstract excerpt

We previously identified dipeptidylpeptidase 10 (DPP10) on chromosome 2 as a human asthma susceptibility gene, through positional cloning. Initial association results were confirmed in many subsequent association studies but the functional role of DPP10 in asthma remains unclear. Using the MRC Harwell N-ethyl-N-nitrosourea (ENU) DNA archive, we identified a point mutation in Dpp10 that caused an amino acid change...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29361513
DOI: 10.1242/dmm.031369
PMCID: PMC5818078

Genes

DPP10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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