Article
Dominant atopy risk mutations identified by mouse forward genetic analysis.
Allergy - 1 Apr 2021
SoRelle Jeffrey A, Chen Zhe, Wang Jianhui, Yue Tao, Choi Jin Huk, Wang Kuan-Wen, Zhong Xue, Hildebrand Sara, Russell Jamie, Scott Lindsay, Xu Darui, Zhan Xiaowei, Bu Chun Hui, Wang Tao, Choi Mihwa, Tang Miao, Ludwig Sara, Zhan Xiaoming, Li Xiaohong, Moresco Eva Marie Y, Beutler Bruce
Abstract excerpt
BACKGROUND: Atopy, the overall tendency to become sensitized to an allergen, is heritable but seldom ascribed to mutations within specific genes. Atopic individuals develop abnormally elevated IgE responses to immunization with potential allergens. To gain insight into the genetic causes of atopy, we carried out a forward genetic screen for atopy in mice. METHODS: We screened mice carrying homozygous and...
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