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Article

Surfactant protein D alters allergic lung responses in mice and human subjects.

The Journal of allergy and clinical immunology - 1 May 2008

Brandt Eric B, Mingler Melissa K, Stevenson Michelle D, Wang Ning, Khurana Hershey Gurjit K, Whitsett Jeffrey A, Rothenberg Marc E

Abstract excerpt

BACKGROUND: Surfactant protein (SP) D has been proposed to be protective in allergic airway responses. OBJECTIVE: We aimed to determine the effect of SP-D deficiency on murine and human airway allergy. METHODS: Immunologic responses of SP-D gene-deficient mice (Sftpd-/-) at baseline and after 4 intranasal Aspergillus fumigatus exposures were assessed. In addition, the significance of a single nucleotide...

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Source

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Identifiers

PMID: 18355911
DOI: 10.1016/j.jaci.2008.02.011
PMCID: PMC4145593

Genes

SFTPD
CCL17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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