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Article

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain.

The Journal of experimental medicine - 14 Jan 2013

Beisner Daniel R, Langerak Petra, Parker Albert E, Dahlberg Carol, Otero Francella J, Sutton Sue E, Poirot Laurent, Barnes Whitney, Young Michael A, Niessen Sherry, Wiltshire Tim, Bodendorf Ursula, Martoglio Bruno, Cravatt Benjamin, Cooke Michael P

Abstract excerpt

B cell development requires tight regulation to allow for the generation of a diverse repertoire while preventing the development of autoreactive cells. We report, using N-ethyl-N-nitrosourea (ENU)-induced mutagenesis, the identification of a mutant mouse (chompB) with a block in early B cell development. The blockade occurs after the transitional 1 (T1) stage and leads to a decrease in mature B cell subsets and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23267013
DOI: 10.1084/jem.20121072
PMCID: PMC3549714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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